Research
The Houlahan lab integrates large-scale, diverse tumour multi-omic data with statistical and machine learning models to uncover the impact of inherited DNA variants on tumour evolution.
Highlighted
Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity
Science
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31 May 2024
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doi:10.1126/science.adh8697
A polygenic two-hit hypothesis for prostate cancer
JNCI: Journal of the National Cancer Institute
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05 Jan 2023
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doi:10.1093/jnci/djad001
Genome-wide germline correlates of the epigenetic landscape of prostate cancer
Nature Medicine
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01 Oct 2019
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doi:10.1038/s41591-019-0579-z
All
2024
Insights on Future Directions in Cancer Research from the AACR NextGen Stars
Cancer Discovery
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04 Sep 2024
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doi:10.1158/2159-8290.CD-24-0774
Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.
Breast cancer research : BCR
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02 Sep 2024
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pmid:39223670
Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity
Science
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31 May 2024
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doi:10.1126/science.adh8697
2023
Deterministic evolution and stringent selection during preneoplasia.
Nature
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31 May 2023
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pmid:37258665
A polygenic two-hit hypothesis for prostate cancer
JNCI: Journal of the National Cancer Institute
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05 Jan 2023
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doi:10.1093/jnci/djad001
2022
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.
Cancer cell
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17 Nov 2022
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pmid:36400020
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Nature genetics
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17 Oct 2022
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pmid:36253572
Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture
Cancer Discovery
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15 Sep 2022
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doi:10.1158/2159-8290.CD-22-0027
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
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27 Jun 2022
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pmid:35760778
2021
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A tumor "personality" test to guide therapeutic decision making.
Cancer cell
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20 May 2021
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pmid:34019808
2020
The DNA methylation landscape of advanced prostate cancer.
Nature genetics
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13 Jul 2020
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pmid:32661416
The landscape of RNA polymerase II–associated chromatin interactions in prostate cancer
Journal of Clinical Investigation
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22 Jun 2020
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doi:10.1172/JCI134260
2019
Genome-wide germline correlates of the epigenetic landscape of prostate cancer
Nature Medicine
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01 Oct 2019
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doi:10.1038/s41591-019-0579-z
Modelling the MYC-driven normal-to-tumour switch in breast cancer.
Disease models & mechanisms
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26 Jul 2019
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pmid:31350286
Molecular Hallmarks of Multiparametric Magnetic Resonance Imaging Visibility in Prostate Cancer.
European urology
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24 Jan 2019
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pmid:30685078
BPG: Seamless, automated and interactive visualization of scientific data.
BMC bioinformatics
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21 Jan 2019
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pmid:30665349
PLATYPUS: A Multiple-View Learning Predictive Framework for Cancer Drug Sensitivity Prediction.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
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01 Jan 2019
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pmid:30864317
2018
Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection.
Genome biology
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06 Nov 2018
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pmid:30400818
Valection: design optimization for validation and verification studies.
BMC bioinformatics
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25 Sep 2018
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pmid:30253747
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
Nature Communications
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29 Aug 2018
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doi:10.1038/s41467-018-05660-0
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.
Cell
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19 Apr 2018
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pmid:29681457
Pathogenic Germline Variants in 10,389 Adult Cancers.
Cell
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05 Apr 2018
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pmid:29625052
Germline contamination and leakage in whole genome somatic single nucleotide variant detection.
BMC bioinformatics
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31 Jan 2018
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pmid:29385983
2017
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.
BMC genomics
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13 Jan 2017
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pmid:28086803
Genomic hallmarks of localized, non-indolent prostate cancer.
Nature
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09 Jan 2017
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pmid:28068672
2015
Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.
Toxicology and applied pharmacology
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29 Jul 2015
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pmid:26232522
Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.
Nature methods
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18 May 2015
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pmid:25984700
2014
Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.
Toxicology
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18 Dec 2014
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pmid:25529477
Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity.
BMC genomics
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03 Dec 2014
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pmid:25467400